Cross-modality registration: Validation and Application in Magnetisation Transfer Imaging

M. Symms, P. Boulby, G. Barker Institute of Neurology, London, United Kingdom, Institute of Psychiatry, London, United Kingdom Synopsis A technique to validate cross-modality registration techniques is described. Serial scans are used from an interleaved MTR measurement sequence that acquires intrinsically registered images with proton density and Magnetisation Transfer weighting. The registration parameters from the serial registration of proton density weighted images are used as a "gold standard" for the serial cross-modality registration, which is performed between the first proton density weighted image and the second magnetisation transfer weighted image. It is then shown that a modified Automated Image Registration technique is capable of performing such cross-modality registrations with a high degree of accuracy.